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Elementarily, it's tobacco and it smokes exceedingly well

Use of nicotine alone, in the doses used by smokers, represents little if any hazard to the user

Our study highlights how tobacco smoking actually deactivates critical proteins, which are the building blocks of our cells, and the impact that can have on our long-term health. The study also identified other factors and processes responsible for creating large numbers of stop-gain mutations, which are also called nonsense mutations

But consider that 10 percent prevalence in 2050 implies that there will be hundreds of thousands of entirely preventable premature deaths from smoking every year