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It seems likely that A622 enzymes catalyze a step (perhaps activation of nicotinic acid or a derived metabolite) prior to the step catalyzed by BBL enzymes [23]

Another consequence of ineffective regulation is that regulators implement ever tougher, more restrictive legislation like the forthcoming review of the European Tobacco Product Directive to try and rectify their previous efforts, rather than giving that original regulation the opportunity to at least be somewhat effective through strong enforcement

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