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Teen smoking is at an all-time low, and the number of smoking adults is plummeting as the practice is increasingly discouraged in public, banned indoors, and taxed so much as to be unaffordable

Image provided by the Australian Government of a proposed plain-packaged cigarette packet

Furthermore, CC-derived tar and carbon monoxide (CO) are known to induce oxidative stress, increase the release of ROS, and activate mitogen-activated protein kinase (MAPK) signaling cascades in immune cells exposed to combustible cigarettes, leading to increased production of inflammatory cytokines 114 (Table 3)

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