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Increased brain release of serotonin and endogenous opioid peptides, as well as the upregulation of opioid receptors, have also been reported in various animals models following nicotine administration (Marty et al., 1985

Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway Garrett, Melanie E