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Also, overexpression of heme oxygenase-1, a stress-induced enzyme that produces endogenous carbon monoxide, has been found to protect dopaminergic neurons from neurotoxicity in an animal model of Parkinsons. In addition, nicotine, a major constituent of cigarette smoke, has been found to be ineffective at slowing the diseases progression in a recently reported clinical trial

Roughly half a dozen federal prosecutors in Minnesota resigned this week, and several supervisors in the criminal section of the Civil Rights Division in Washington gave notice of their departures, according to people familiar with the matter

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