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The time-to-event (year) was defined as the duration from the beginning of the follow-up to the date of cancer diagnosis, censoring, or the end of follow-up, whichever occurred first

A report examining PMI data on Sprague Dawley rats exposed to IQOS smoke or CS for 90 days observed increased markers of acute hepatotoxicity, including liver weight and alanine aminotransferase, in the IQOS-exposed group 54

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