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E-cigarettes and health outcomes Ensuring appropriate evidence-based policy and practice relating to e-cigarettes requires systematic identification, review and integration of large-scale contemporary evidence on their effects on health

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Nevertheless, a significant number of biomarker-based studies, cell/ in vitro and animal studies did indicate that e-cigarette exposure can result in oxidative stress, cellular apoptosis, DNA damage, genotoxicity, and tumor growth (Figure 2, and Supplementary file Materials 2 and 3), all of which can potentially increase risk of developing lung cancer or progression of any cancer