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Physicians should encourage their patients to quit smoking using pharmacological strategies and promote physical activities that minimize weight gain and positively impact life expectancy and quality of life

However, studies in this area have not yet been conducted in humans

Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety

Regulations : Strict regulations on advertising, packaging, and selling practices contribute to the overall cost of cigarettes