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ANZ J Surg 88:82530
The activation of different signaling pathways due to exposure to nicotine may be another factor in reducing sperm motility because several animal studies demonstrated that nicotine exposure ( in vivo ) increases the levels of proteins primarily implicated in the mitogen-activated protein kinase (MAPK) signaling pathway [40, 41]
If the effect sizes obtained from the frailty analysis were to be similar to the effect sizes obtained from the Mendelian Randomization analysis, then it would be suggested that the survival bias is large enough to explain the results
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