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Summary Keywords monocyte-derived alveolar macrophages, single-cell RNA-sequencing, COPD, lung inflammation, IRAK4 inhibitor, neutrophils, smoking, tissue remodeling Citation Wohnhaas CT, Baler K, Watson CK, Shen Y, Leparc GG, Tilp C, Heinemann F, Kind D, Stierstorfer B, Deli D, Brunner T, Gantner F, Schultze JL, Viollet C and Baum P (2024) Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling