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The agency may suspend or withdraw a marketing granted order issued under the PMTA pathway for a variety of reasons if the agency determines the continued marketing of a product no longer meets the necessary public health standard, such as if there is a notable increase in youth initiation

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Sudden onset of mood instability and paranoid symptoms, within one week after use, but as early as 24 hours after use

More recently, Altria has divested from JUUL and acquired NJOY Holdings , gaining access to NJOY Ace, one of the few pod-based e-cigarette products to have received marketing authorization from the FDA