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Because the tobacco industry has already found ways to get around restrictions that banned a few flavored tobacco products and made it illegal to sell tobacco to anyone under 21

Another ICD-10 indicator of dependence refers to the occurrence of a withdrawal syndrome,16 an aversive constellation of signs/symptoms that occurs spontaneously following abrupt termination of the dependence-producing substance.81 Evidence for this withdrawal syndrome might come from laboratory studies in which exclusive waterpipe smokers are required to abstain from all tobacco use prior to completing standardised questionnaires used to assess nicotine/tobacco abstinence

A: TMV coat protein gene system