Establishing product standards is crucial, including setting maximum limits on nicotine concentration and regulating pH to reduce free base nicotine levels and abuse liability, requiring full disclosure of ingredients, and mandating standardized, clear labeling of nicotine content per pouch (7, 10, 12, 13)
This discreet, convenient form of nicotine is simple to use and travel-friendly
This is due in part to cultural factors, as smoking is more socially acceptable in Japan than in many other countries, and many people prefer to smoke smaller amounts at a time
n=10) whilst in the catheterisation laboratory, followed by repeat coronary flow reserve measurement (Lombardi et al., 2020)