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It might be surprising that the downregulation of HIF-1 under normoxic conditions had downstream effects on target gene expression and glycolysis in the present study because HIF-1 is usually considered a hypoxia-regulated transcription factor

The majority of studies rely on indirect measures, such as salivary melatonin or urinary melatonin metabolite samples to monitor its circulating concentrations, which may not capture fluctuations accurately