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While the precise cellular and network mechanisms that underly nicotine induced seizures are not fully elucidated, the cholinergic nuclei in the brainstem and basal forebrain play key roles in arousal and attention via their effects on cortical tone and modulation of such systems could therefore theoretically affect the seizure threshold

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Using pre-made coils on a regulated device is much safer than using hand-built coils on an unregulated device, but hazards like device failure, short circuit, or even explosion are dangerous to users