Check with your doctor immediately if any of the following side effects occur: Incidence not known Black, tarry stools bleeding gums blistering, peeling, loosening of the skin blood in the urine or stools blurred vision or other change in vision chest pain or tightness chills cloudy urine confusion cough cracks in the skin decreased urine diarrhea difficulty in moving difficulty with swallowing dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position dry mouth eye pain fast heartbeat fever greatly decreased frequency of urination or amount of urine hives, itching, or skin rash increased thirst joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs loss of heat from the body mood or mental changes muscle aches, cramps, pains, or stiffness muscle cramps in the hands, arms, feet, legs, or face numbness and tingling around the mouth, fingertips, or feet painful or difficult urination pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips or tongue red, irritated eyes red skin lesions, often with a purple center red, swollen skin scaly skin seizures sensitivity of the eye to light severe stomach cramps and pain sore throat sores, ulcers, or white spots in the mouth or on the lips stomach tenderness sweating swelling of the breasts or breast soreness in both females and males swelling of the feet or lower legs tearing trembling trouble breathing unusual bleeding or bruising unusual tiredness or weakness watery and severe diarrhea, which may also be bloody Some side effects may occur that usually do not need medical attention

At the same time, sensory improvements begin
Joseph McClernon and Maggie Sweitzer, also of the Duke University School of Medicine in Durham, North Carolina
For more than a couple of hundred years, every little farm across the state grew at least a little bit of tobacco