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The transition to a more severe expression of smoking-associated disease is marked by the impaired ability of macrophages to kill bacteria or viruses, the loss of ability to remove dead cells, the degradation and chemical modification of the extracellular matrix, the increasing retention of oligoclonally expanded CD8+ T cells and the induction of interleukin-17-secreting effector T cells

I have wondered why it is that if the tobacco people have no ability to increase the size of their market through advertising, the very few heads of advertising agencies who have refused to accept cigarette-advertising accounts (these include such shrewd manipulators of the market as William Bernbach, of Doyle Dane Bernbach, and the Benton & Bowles agency), in the belief that they would harm the public if they did, should have failed to recognize this supposed basic economic principle of limited advertising effectiveness

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Archived from the original (PDF) on 2 June 2015