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Adding to their detrimental health impact was the fact that while all tobacco leaves contain some nicotine (some more than others, e.g., Cypriot Latakia contains one of the least), cigarette manufacturers were able to add more nicotine and other harmful and addictive chemicals to cigarettes, making them even more damaging and more addictive than the natural leaves smoked in a pipe

Pack years also influence clinical decisions, such as determining eligibility for lung cancer screenings or tailoring treatment plans to match exposure levels