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preferred or dupilumab for moderate-severe allergic asthma with 1 OCS exacerbation/year Eosinophilic (eos 300 cells/L): Mepolizumab (Nucala, anti-IL5), benralizumab (Fasenra, anti-IL5R), reslizumab (Cinqair IV, anti-IL5), or dupilumab (anti-IL4R/IL-13) Mixed/Broad T2: Dupilumab (atopic dermatitis or EoE comorbidity preferred) or tezepelumab (Tezspire, anti-TSLP efficacy across all phenotypes including T2-low) Aspirin-exacerbated respiratory disease (AERD): Dupilumab preferred

There were also no interactions between Total Smoke Exposure groups and time (between-subjects test, F 6,666 = 1.16, p = 0.32), after controlling for age, PM10, and cycle length

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Stress Issue: Smokers are often exposed to stress on daily basis than non smokers