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Furthermore, smoking induces vascular vasoconstriction, sinusoidal endothelial dysfunction, and smooth muscle proliferation, leading to hypoxia, capillarization of sinusoids, and further activation of HSCs [18]

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A December 4, 2019 Tax Foundation report concluded that Excessive tax rates on cigarettes approach de fact prohibition in some states, inducing black and gray market movement of tobacco products into high-tax states from low-tax states and foreign sources. A December 2015 Department of State report, The Global Illicit Trade in Tobacco: A Threat to National Security, found that international smuggling is a lucrative crime for some terror groups and a potential revenue sources to finance acts of terror and annually causes losses to state and local governments of between $3 billion and $7 billion