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Delirium status during ICU stay was determined using a combination of ICD-10 diagnosis code ( Figure 1 2.2 Smoking status The smoking status of patients was determined through the pre-ops anesthesia anamnesis in the form of pack-years (the unit of measurement used to quantify the level of exposure to cigarette smoking, calculated by multiplying the number of packs of cigarettes smoked per day by the number of years the person has smoked) ( 2.3 Confounding factors To minimize the influence of confounding variables, we excluded quitters from the study to account for potential lingering effects of nicotine ( To uniformly compare medication use across patients, we standardized the analysis timeframe