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Treatment Implications The advantage of broadening our understanding about the underlying neurobiology of this comorbidity is that it may lead to more novel, targeted treatments to be developed

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Methamphetamine's extreme addiction potential results from: Powerful Dopamine Release: Can cause extremely large increases in dopamine, far exceeding natural rewards Rapid Onset: Smoking or injecting produces immediate, intense euphoria Long Duration: Effects last 824 hours, enabling extended binges Severe Neurotoxicity: Causes lasting damage to dopamine and serotonin systems Cognitive Impairment: Memory, attention, and decision-making deficits can persist in recovery High Relapse Rates: Very high relapse rates within several years of treatment, according to NIDA research Methamphetamine is also increasingly implicated in overdose deaths rather than only in long-term harm, a shift driven largely by contamination of the stimulant supply with synthetic opioids