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Key Points Tobacco products cause a variety of cancers, including those of the lung, oral cavity, nasal cavity, larynx, oropharynx, hypopharynx, oesophagus, stomach, liver, pancreas, bladder, ureter, kidney and cervix, and myeloid leukaemia

This distinction is clinically important: metformin may be prescribed for its approved indication (diabetes) in a patient with coexisting fatty liver, but prescribing it solely to treat fatty liver constitutes off-label use without robust supporting evidence

Protein oxidation as evidenced by carbonyl formation was measured by reaction with 2,4-dinitrophenyl hydrazine similar to that done before in our laboratory (4)

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