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Surgeon General, in addition to nicotine, e-cigarettes can contain harmful and potentially harmful ingredients, including: ultrafine particles that can be inhaled deep into the lungs flavorants such as diacetyl, a chemical linked to serious lung disease volatile organic compounds heavy metals, such as nickel, tin, and lead The Surgeon General reports that, the health effects and potentially harmful doses of heated and aerosolized constituents of e-cigarette liquidsincluding solvents, flavorants, and toxicantsare not completely understood