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3 Nicotine pharmacology and cardiovascular effects 3.1 Mechanisms of nicotine action As detailed by Benowitz (22) in his comprehensive review of nicotine pharmacology, nicotines addictive potential stems from its complex interaction with the nervous system, involving rapid central nervous system penetration and subsequent activation of neural reward pathways

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Cigarettes, like many consumable products, have a shelf life that can be affected by various factors: Packaging: Cigarettes are typically packaged in cardboard boxes and sealed in cellophane to keep them fresh