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Numerous studies have examined the popularity and consumer perceptions of cigarettes branded as natural, and in 2015 the FDA sent a letter to Santa Fe Tobacco asserting that some of its labeling practices explicitly and/or implicitly represent that Natural American cigarettes pose less of a risk than other tobacco products

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However epidemiological, casecontrol, and cohort studies have shown no increased risk of cancer from smoking cannabis [133, 157,158,159] and there is a lack of DNA adducts in animal models of chronic cannabis exposure [160]