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46 47 48 Laboratory studies have also shown that nicotine can reduce the symptoms of ADHD and act in a similar way to medication used to treat ADHD, which may explain why people with ADHD use tobacco to self-medicate

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3.3 Example reiterating the importance of involving the regulatory agency early in the experimental development process and to clearly describe the NAMs In the decision summary of a PMTA where five separate in vitro organotypic studies were submitted, it was noted The experimental approach taken in these studies included using methods that are exploratory, have not been independently validated, and have unknown utility for regulatory use

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