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Researchers found significant, reciprocal associations between [e-cigarette] and cigarette use. The data show that more frequent e-cigarette use at one point in time during the study predicted more frequent cigarette use at a later time during the study, and vice versa

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Results from preclinical and single-exposure clinical studies imply negative impacts of ENDS usage on myocardial structure, function, and electrophysiology, all related to cardiovascular disease development [101,102,103]

The exact positioning of the non-return valves in the inhalation and exhalation parts of the circuit may affect the effective dead space to some extent, but their presence in both parts, and a small orinasal pocket volume, are critical to minimising carbon dioxide buildup, and consequent hypercapnia