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To make sure their findings werent accounting for cigarette smokers switching to e-cigarettes specifically because of existing health issues (rather than the vaping itself causing these issues), the researchers only included people in the study who reported having no respiratory issues when they entered PATH, adjusting for a comprehensive set of health conditions

Recent studies have shown that pulmonary vascular endothelial cell apoptosis also initiates and participates in the pathogenesis of COPD [25]

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