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Smoking cigarettes can cause a decrease in the three main factors that determine sperm quality: Sperm Count an average 22% decrease in men who smoke regularly Morphology the shape of the sperm Motility the ability of the sperm to swim forward and penetrate an egg Smoking and Erectile Dysfunction Smoking has also been linked to erectile dysfunction and impotence in men of all ages

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While 5% (50mg) may be legal in the U.S., its generally recommended only for heavy smokers or those in the early stages of quitting

The prior probabilities of a causal variant being associated only with Trait 1 (i.e., Target) and only with Trait 2 (i.e., OP) are set at 10 4