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In human microvascular endothelial (HMEC-1) cells, treatment with non-cytotoxic concentrations of sodium arsenite (0.5 and 1 M for 24 h) reduced the thrombin signaling by decreasing the phosphorylation levels of the endothelial nitrogen oxide synthase (eNOS), lowering NO synthesis and cytosolic Ca 2+ levels, which could lead to endothelial dysfunction (136)

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