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That band was Black Sabbath, almost singlehandedly defining the sound that came to be known as heavy metal thanks to such tracks as "Paranoid," "Iron Man," and "War Pigs." Throughout the 1970s, Osbourne became legendary for rock-star excess so much so that his bandmates ultimately fired him

I was very down on myself

When you accept that you are anxious you take the power away from the feeling

The animal studies were approved by the Animal Experimental Ethical Committee of Fudan University (number: 2019 Huashan Hospital JS-112) and performed in accordance with the guidelines for the care and use of laboratory animals set by Fudan University (Shanghai, China)