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"This will be a dramatic change in what a cigarette package looks like, no doubt about it," Hamburg said, later adding: "It will change the consumer response to a package of cigarettes, but frankly, that's what we want." Thomas Glynn, director of cancer science and trends for the American Cancer Society, said the old labels have been virtually invisible because they're small and have been around for so long

With these assumptions in mind, Equation 2 becomes Cons it = Smoke it * f(Trend t ) where f(Trend t ) represents the above-described linear function of smoking intensity and under-reporting

Existing literature on the relationship between smoking and specific health outcomes is prolific, including meta-analyses, cohort studies and casecontrol studies analyzing the risk of outcomes such as lung cancer 5,6,7 , chronic obstructive pulmonary disease (COPD) 8,9,10 and ischemic heart disease 11,12,13,14 due to smoking

Some studies analyze the actual tobacco in the cigarette to determine how much nicotine it contains before its smoked