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Gallstone Risk Factors You're more likely to get gallstones if you: Have a family history of them Are a woman or assigned female at birth Are over age 40 Are of Native American or Mexican descent Have obesity Have a diet high in fat and cholesterol but low in fiber Dont get much exercise Use estrogen-based birth control or hormone replacement therapy Add estrogen to your body with feminizing hormone therapy Have diabetes Have an intestinal disease such as Crohns Have hemolytic anemia or cirrhosis of the liver Take medicine to lower your cholesterol Lose a lot of weight in a short time (like from weight loss surgery) Fast on a regular basis Gallstones in pregnancy During pregnancy, your body makes extra hormones called estrogen and progesterone