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The peer-reviewed, two-part regression analysis is too complex to describe here in detail, and the technical discussion has been relegated to "Appendix A: The Econometric Analysis." In general terms, however, the model compares legal, per-capita sales of cigarettes to survey data on the percentage of smokers in each state (the survey data comes from the "Behavioral Risk Factor Surveillance System" administered by the Centers for Disease Control and Prevention)

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Nicotine gets around the body via the bloodstream, binding at sites including the liver, kidney, spleen, and brain, and is lowest in fat tissue

Many people turn to nicotine replacement products, such as gum and patches, to help them quit smoking