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The linear mixed model assesses changes in PASI scores and interaction between time and group (type of treatment, smoking status, etc.)

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She noted, for example, that using a substance frequently to get to sleep may lead to tolerance, or needing more of it to get the same effect."In other words," Patrick explained, "Rather than resulting in better sleep, it may lead to additional sleep problems and escalating substance use."The study is one of the first nationwide efforts to explore why young adults use substances to manage sleep issues