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The center has an annual budget of more than $450 million, much of it funded by the industry, and more than 365 employees, about 115 of whom work on the application reviews

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It is becoming clear that e-cigarettes used as consumer products are not effective as smoking cessation devices, while e-cigarettes given therapeutically in controlled clinical settings may help some people quit smoking

Using CSM-II, among adolescents who ever used electronic cigarettes in the third wave, six percent of individuals began smoking cigarettes in the fourth wave and continued to smoke in the fifth wave, compared to one percent among those who never used electronic cigarettes