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One of the possible causes is that nicotine in tobacco smoke leads to oxidative stress and hence insufficient oxygen is supplied to the skin, which results in tissue ischemia and blood vessel occlusion

If budget cuts are needed, I dont know why were starting at the dinner plate, Postel said

Cigarette smoking is one of the most important modifiable risk factor for DM [12]

But he may, and he probably will, write something which will move the general world more profoundly, touching it more closely, in the manner of the great writers, in whom beauty has not been more beautiful than in writers less great, but has come to men with a more splendid energy