japanese pipe tobacco How to use a Kiseru Tobacco culture, c. 1910. |

Even when inhaled, factors like lung surface area, retention time, and nicotine's chemical form affect absorption

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Nicotine salts allow users to inhale higher levels of nicotine with less discomfort leading to a higher addictive potential

All experiments were performed in accordance with guidelines/regulations which were reviewed and approved by the joint Clinical Research Ethics Board of the University of British Columbia and BC Cancer (#H12-00727)