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In pregnant Balb/c [H-2 d ] mice treated with 4 ppm of arsenic trioxide from the time of conception until parturition, the offspring exhibited low levels of IgG 2a , reduced allogeneic stimulation of CD4 + T cells, reduced number of splenic CD4 + and CD8 + lymphocytes, and a higher susceptibility to Escherichia coli infection (182)

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