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- People with significant liver disease (the 9-month monkey toxicology study showed dose-dependent periportal vacuolation in hepatocytes that the FDA flagged as a possible safety signal)

Nasal and Topical Applications Nasal sprays and gels, and topical creams and gels, are other ways to get Vitamin B12

Some studies also suggest it may promote nerve regeneration and protect against brain injury by modulating dopamine and serotonin pathways