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For CNS autoimmune syndromes, well-validated disease-specific fluid biomarkers already guide diagnosis and management: serum and CSF anti-AQP4 and anti-MOG autoantibodies are clinically established for discriminating neuromyelitis optica spectrum disorder (NMOSD), MOG-antibody disease and MS-like presentations, and serial antibody titers sometimes correlate with relapse risk and radiological activity (152, 153)

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It is not legally available for human use outside authorized clinical trials, and PlexusDx does not sell or supply it

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