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Sample size calculation The sample size calculation was based on the assumptions of a mean difference in the primary endpoint CDR-SB score of 0.44 points (relating to a 20% difference between semaglutide and placebo when assuming a mean increase in the placebo arm of 2.2 points), standard deviation of 2.6 points, and one-sided significance level of 0.025

Increased fat mass and obesity-associated protein (FTO) expression has been detected in FLSs from RA patients and synovial cells from adjuvant-induced arthritis (AIA) mice (a mouse model induced by intradermal injection of CFA)

Multiple studies have provided evidence indicating the protective role of ghrelin in the development of esophageal disorders, gastric disorders, GI functional disorders, and CC

In Germany, statutory health insurers generally do not cover medication for weight loss