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It works by transferring a methyl group from methylfolate to homocysteine.2 Second, it transforms methylfolate into tetrahydrofolate, a crucial DNA creation and repair molecule.3 This process may not work properly at times for people with MTHFR mutations, leading to higher homocysteine levels and lower tetrahydrofolate levels, which can disrupt DNA repair and other vital processes.4 How Candida Overgrowth Impacts Methylation Some chemicals can stop methionine synthase from working the way it should, and one of these is acetaldehyde