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The potential for posttreatment sensitization (e.g., rebound craving) upon discontinuation of GLP1As requires careful consideration, particularly in adolescents vulnerable to substance misuse and weight cycling
Sex-specific increases in subcutaneous and visceral fat in response to the WD Both sexes gained subcutaneous fat (IWAT) on a WD, but only females on the WD gained visceral fat (GWAT)
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Sexual function changes that are primarily neurochemical, meaning dopamine or serotonin mediated, typically resolve within one to two months of discontinuation as the brain reward system recalibrates
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