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The logic is that local administration creates higher peptide concentrations at the relevant tissue

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Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of SNAC, an absorption enhancer for RYBELSUS , and because there are alternative formulations of semaglutide that do not contain SNAC that can be used during lactation, advise patients that breastfeeding is not recommended during treatment with RYBELSUS Please click here for RYBELSUS Prescribing Information, including Boxed Warning

To best manage its side effects, youll undergo whats called a titration schedule: a gradual, weeks-long escalation of the dose you take