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[2] If you're planning pregnancy, contact your provider well in advance, as these medications should be discontinued (semaglutide at least 2 months before planned conception) due to limited safety data in pregnancy

This is both a cosmetic concern and a safety consideration

Pulmonary aspiration (when food or liquid from the stomach enters the lungs) has occurred in some people taking GLP-1 medications , including Zepbound, while undergoing surgery requiring sedation, even when instructed to fast before the surgery

However, in a separate study, bilateral subdiaphragmatic vagotomy abolished both the anorectic effects of PYY 336 and its ability to induce Fos expression in the ARC of rats following peripheral administration, indicating blockade of hypothalamic activation (112)