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As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19

Obesity is equally defined in older and younger adults using a BMI 30 kg/m 2 , with ethnic specific BMI thresholds [14], although surrogate markers of fat mass and distribution, such as waist circumference (WC) and height-to-weight ratio, may more accurately define body composition in older adults [15]

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They found that creatine supplementation improved participants' handgrip strength, lean tissue mass, and upper-body muscle strength with few adverse effects