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Commit to Lifestyle Changes: GLP-1 therapy is most effective alongside a balanced diet and regular exercise

Obesity reduces SIRT1 activity in liver and adipose tissue 29, 30

For example, a meta-analysis of several global multicenter clinical trials involving 12,651 patients found that semaglutide reduced AF episodes by 42% in individuals at high cardiovascular risk [28]

The Vascular Hypometabolism Hypothesis: Reframing Dementia as an Energy and Delivery Problem A growing body of evidence suggests that dementia and Alzheimers disease are driven less by isolated protein aggregates and more by a chronic failure of blood flow, nutrient delivery, and metabolic precision in the brain, a framework often described as the vascular hypometabolism hypothesis [4, 5]