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Generally, bariatric surgery is recommended for people with: A BMI between 35 and 39.9 A health condition such as: Type 2 diabetes Sleep apnea High blood pressure Osteoarthritis A history of failed medically-supervised dieting Gastric Bypass A gastric bypass is a weight-loss surgery that has been performed for over 50 years, making it the most experienced bariatric operation

In mice, however, tirzepatide is selective for GLP1R over GIPR, and its insulinotropic and overall therapeutic efficacy is equivalent or non-superior to semaglutide (GLP1R agonist) 10,11

So when someone quotes about 1 in 5 people get nausea and someone else says more like half, the difference is dose and indication, not disagreement

Lancet 2006;368:1696-1705